METHODS FOR ENHANCING THE IMMUNOSTIMULATION POTENCY OF ALUMINUM SALT-ADSORBED VACCINES

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专利权人:

THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE ARMY

发明人:

ALVING, CARL, R.,KIM, JEROME, H.,RAO, MANGALA,ALVING, CARL,KIM, JEROME, H.,RAO, MANGALA

申请号：

SG11201607404P

公开号：

SG11201607404PA

申请日:

2014.07.09

申请国别(地区):

SG

年份:

2016

代理人:

摘要：

Provided herein are (1) a method of mixing an aluminum salt-adsorbed immunogen with a monophosphoryl lipid A (MPLA)-containing liposome (L(MPLA)), and (2) the resulting immunogenic composition. The resulting immunogenic composition has an enhanced immunostimulation potency compared with either a composition comprising the uncapsulated immunogen mixed with the L(MPLA) or the aluminum salt-adsorbed immunogen alone.

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