LUTZ, CHRISTIAN,ANDERL, JAN,MULLER, CHRISTOPH,SIMON, WERNER,WERNER-SIMON, SUSANNE,HECHLER, TORSTEN,KULKE, MICHAEL
申请号：
CA3015138
公开号：
CA3015138A1
申请日:
2017.03.02
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6'-deoxy position； and (ii) an amino acid 8 with an S-deoxy position； (b) a target-binding moiety； and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.
