PROBLEM TO BE SOLVED: To provide a manufacturing method of a biological tissue hardened body preservable in the state similar to the living state unaccompanied by contraction in a short time.SOLUTION: A biological tissue is impregnated into mixed solution acquired by combining a monofunctional vinyl monomer, a polyfunctional vinyl monomer, and a solvent together, and then polymerized by being irradiated with an ionizing radiation.COPYRIGHT: (C)2009,JPO&INPIT【課題】短時間で、かつ収縮を伴わないで生きた状態に近い形で保存が可能な生物組織硬化体の製造方法を提供する。【解決手段】生物組織を、単官能性ビニルモノマー、多官能性ビニルモノマー、及び溶媒を組合せた混合溶液に含浸させた後、電離性放射線を照射することで重合させる。【選択図】図1