Ryu, Je Ho,Kim, Shin Ae,Ryu, Keun Ho,Kim, Jae Sun,Kim, Nam Ho,Han, Hye Young,Kim, Yong Hyuk,Youn, Won-No,Lee, Yoon-Jung,Son, Hyun Joo,Lee, Bong-Yong,Park, Sung Hoon,Lee, Ju Young,Lee, Hyun Jung,Jung,
申请号：
AU2011249167
公开号：
AU2011249167B2
申请日:
2011.05.04
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human- derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LAD A), insulin tolerance syndromes, obesity, impaired glucose tolerane (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
