RYU, JE HO,KIM, SHIN AE,RYU, KEUN HO,KIM, JAE SUN,KIM, NAM HO,HAN, HYE YOUNG,KIM, YONG HYUK,YOUN, WON-NO,LEE, YOON-JUNG,SON, HYUN JOO,LEE, BONG-YONG,PARK, SUNG HOON,LEE, JU YOUNG,LEE, HYUN JUNG,JUNG,
申请号：
EP11777588
公开号：
EP2566859A4
申请日:
2011.05.04
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11&bgr；-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11&bgr；-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11&bgr；-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
