Shin Ae Kim;Won-No Youn;Hoe Chul Jung;Jae Sun Kim;Ju Young Lee;Keun Ho Ryu;Sung Hoon Park;Yong Hyuk Kim;Hyun Jung Lee;Young ;Nam Ho Kim;Bong-Yong Lee;Hye Young Han;Hyun Joo Son;Je Ho Ryu;Yoon-Jung Lee
发明人:
Je Ho Ryu,Shin Ae Kim,Keun Ho Ryu,Jae Sun Kim,Nam Ho Kim,Hye Young Han,Yong Hyuk Kim,Won-No Youn,Yoon-Jung Lee,Hyun Joo Son,Bong-Yong Lee,Sung Hoon Park,Ju Young Lee,Hyun Jung Lee,Hoe Chul Jung,Young
申请号：
US13696400
公开号：
US09096571B2
申请日:
2011.05.04
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
