An in-vivo device may allocate a sensing window in a work cycle for sensing and processing localization signals to determine the location/orientation of the in-vivo device. The in-vivo device may use a timing unit to schedule transmission of data frames and the sensing of the localization signals relative to a reference time embedded in work cycles. The timing unit may produce a clock signal based on which the in-vivo device may measure time specifics, which define the sensing window, relative to the reference time. A receiver may use data embedded in data frames to restore the clock signal and the reference time, and, from them, and using identical or similar time specifics, generate a synchronization signal for a localization signals source (LSS) to enable the LSS to generate localization signals in synchronization with the sensing windows.
