BONNERT, ROGER VICTOR,COX, RHONA JANE,DE SOUSA, SIMON,DICKINSON, MARK,HUNT, SIMON FRASER,MEGHANI, PREMJI,PIMM, AUSTEN,SANGANEE, HISTESH JAYANTILAL,BURKAMP, FRANK
申请号：
PE2012001093
公开号：
PE20121529A1
申请日:
2008.01.11
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It refers to the compounds produced from the pyridine derivative (I) in formula (I), among which: A is CA1； E is CE1； W is CH2； R1 is a phenyl substitute, or an alternative isocyclohexane substitute； R2 is NHC (o) R3； R3 is a C1-4 tar substitute, among other things, an alternative to c3-7 cyclohexane, Or alternative heterohalides； A1, E1 and G1 are independent h or halogen. It is a preferred compound: n - {cis-4 - [1 - (4 '-- [(3R, 5S) - 3, 5-dimethylpiperazin-1-il] metal] - bifenil-3-il-6-fluoro-2, 4-dioxo-1, 4-dihydropiride [2, 3-d] pirimidin-3 (2H) - Il] cyclohexil} - 2-methyl-1, 3-tiazol-4-carboxamida,There are others He also mentioned a drug synthesis and a preparation procedure. These compounds are PDE4 inhibitors and are useful in the treatment of asthma, bronchitis, osteoporosis, arthritis and psychosis.SE REFIERE A COMPUESTOS DERIVADOS DE PIRIDOPIRIMIDINA DE FORMULA (I) DONDE: A ES CA1； E ES CE1； W ES CH2； Y ES CH2； R1 ES FENILO SUSTITUIDO CON FENILO, O HETEROCICLILO OPCIONALMENTE SUSTITUIDO； R2 ES NHC(O)R3； R3 ES ALQUILO C1-4 SUSTITUIDO CON HETEROARILO ENTRE OTROS, CICLOALQUILO C3-7 OPCIONALMENTE SUSTITUIDO, O HETEROARILO OPCIONALMENTE SUSTITUIDO CON HALO, ENTRE OTROS； A1, E1 Y G1 SON INDEPENDIENTEMENTE H O HALOGENO. ES UN COMPUESTO PREFERIDO: N-{CIS-4-[1-(4'-{[(3R,5S)-3,5-DIMETILPIPERAZIN-1-IL]METIL}BIFENIL-3-IL)-6-FLUORO-2,4-DIOXO-1,4-DIHIDROPIRIDO[2,3-d]PIRIMIDIN-3(2H)-IL]CICLOHEXIL}-2-METIL-1,3-TIAZOL-4-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE PDE4 SIENDO UTIL EN EL TRATAMIENTO DE ASMA, BRONQUITIS, OSTEOPOROSIS, ARTRITIS, PSORIASIS
