The present invention pertains to a method for lyophilising particles comprising frozen liquid having a pharmaceutical compound contained therein, comprising providing a heat conducting container having a bottom and side walls, filling the container with a bed of the particles, the bed comprising multiple layers of the particles and having an aspect ratio of not less than 1, providing a heat source above a top layer of the particles, the heat source having a surface directed to a top layer of the bed, which surface has an emissivity coefficient of at least 0.4, subjeting the particles filled in the container to a reduced pressure, heating at least the bottom of the container and the said surface to provide heat to the particles to support sublimation of the frozen liquid at the reduced pressure, and after the frozen liquid is sublimated, stopping the provision of heat to the particles. The invention also pertains to a pharmaceutical pack comprising a container having contained therein at least one particle obtained via this method.本發明係關於一種包含冷凍液體之顆粒的冷凍乾燥方法,該冷凍液體具有藥學化合物於其中,該方法包含提供一具有底部及側壁之導熱容器;以顆粒床填充該容器,該床包含多層顆粒且具有不少於1之縱橫比;在顆粒頂層上方提供熱源,該熱源具有一朝向床的頂層之表面,該表面具有至少0.4之發射係數;使容器中所填充之顆粒減壓;至少加熱容器之底部及該表面以提供熱給顆粒,以在減壓下支持冷凍液體之昇華;及在冷凍液體被昇華之後,停止提供熱給顆粒。本發明也關於一種藥學包,其包含容器,且該容器中具有至少一種藉由此方法所得之顆粒。1...冷凍乾燥器2...殼體10...處理單元11...泵單元12...冷卻單元
