Biemans, Rogier,Middelbeek, Hans Almer,Kirkels, Monique
申请号：
AU2009207722
公开号：
AU2009207722B2
申请日:
2009.01.20
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention pertains to a method for lyophilising particles comprisingfrozen liquid having a pharmaceutical compound contained therein, comprisingproviding a heat conducting container having a bottom and side walls, fillingthe container with a bed of the particles, the bed comprising multiple layersof the particles and having an aspect ratio of not less than 1, providing a heatsource above a top layer of the particles, the heat source having a surface directedto a top layer of the bed, which surface has an emissivity coefficient of at least0.4, subjecting the particles filled in the container to a reduced pressure,heating at least the bottom of the container and the said surface to provide heatto the particles to support sublimation of the frozen liquid at the reduced pressure,and after the frozen liquid is sublimated, stopping the provision of heat to theparticles. The invention also pertains to a pharmaceutical pack comprisinga container having contained therein at least one particle obtained via thismethod.
