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METHOD FOR LYOPHILIZING PARTICLES CONTAINING THE PHARMACEUTICAL COMPOSITION THEREIN AND THE PHARMACEUTICAL PACKAGING CONTAINING SUCH PARTICLES
专利权人:
ИНТЕРВЕТ ИНТЕРНЭШНЛ Б.В. (NL)
发明人:
МИДДЕЛБЕК Ханс Алмер (NL),КИРКЕЛС Моник (NL),БИМАНС Рогир (NL)
申请号:
RU2010134899/15
公开号:
RU2010134899A
申请日:
2009.01.20
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. The method of lyophilization of particles containing frozen liquid and having a pharmaceutical composition contained in them, including:! - providing a heat-conducting container having a bottom and side walls,! - filling the container with a layer of particles, while the layer includes many layers of particles and has an aspect ratio of not less than 1,! - providing a heat source above the upper layer of particles, wherein the heat source has a surface facing the upper layer of the layer, where this surface is characterized by an emissivity of at least 0.4,! - impact on particles filling the container with reduced pressure! - heating at least the bottom of the container and said surface to supply heat particles in order to ensure sublimation of the frozen liquid under reduced pressure,! - after sublimation of the frozen liquid, the termination of the supply of heat to the particles. ! 2. The method according to claim 1, characterized in that a heat source is provided, the surface of which is characterized by an emissivity of at least 0.7. ! 3. The method according to claim 1 or 2, characterized in that the aspect ratio for the layer is not less than 5, in particular not less than 10.! 4. The method according to claim 1, characterized in that both the bottom and side walls of the container have a surface facing the layer of particles, each of these surfaces having an emissivity of at least 0.4, in particular at least 0 , 7. ! 5. The method according to claim 1, characterized in that the bottom of the container is heated using the first heating plate, while providing a source of1. Способ лиофилизации частиц, содержащих замороженную жидкость и имеющих содержащийся в них фармацевтический состав, включающий: ! - предусматривание теплопроводящего контейнера, имеющего днище и боковые стенки, ! - заполнение контейнера слоем частиц, при этом слой включает множество пластов частиц и имеет аспектное соотношение, не меньше, чем 1, ! - предусматривание источника тепла над
来源网站:
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