CHADWICK TERENCE KING,WILLIAM CHRISTIAN III FANSLOW,JOHN M. DELANEY
申请号：
ARP120103531
公开号：
AR093186A1
申请日:
2012.09.25
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: a Protein Antigen binding CD27L comprising: a) a light chain variable domain with at least 90% identity with the Amino Acid Sequence SEQ ID no. described in SEQ ID no. 63, 64, SEQ ID no. 65, SEQ ID no. 66, SEQ ID no. 67, SEQ ID no. 68, SEQ ID no. 69Or SEQ ID no. 70 (b) a variable domain of heavy chain with at least 90% identity with the Amino Acid Sequence described in SEQ ID no. 17, SEQ ID no. 18, SEQ ID no. 19, SEQ ID no. 20, SEQ ID no. 21, SEQ ID no. 22, SEQ ID no. 23 or seq ID no. 24 or (c) the variable domain of light chain A a) and the variable domain of heavy chain (b).Claim 6: CD27L Antigen Binding Protein according to claim 4 or 5, where the variable domain of heavy chain has no more than five additions, deletions or substitutions of amino acids from the Amino Acid Sequence described in SEQ ID no. 17, SEQ ID no. 18 SEQ ID no. 19, SEQ ID no. 20, SEQ ID no. 21, SEQ ID no. 22, SEQ ID no. 23, or SEQ ID no. 24.Claim: The 40 CD27L Antigen Binding Protein according to claim 39, where the Connector comprises MCC. Claim 46: the composition of Protein Antigen binding CD27L according to claim 44, where the average number of DM1 molecules by Antigen Binding Protein CD27L is about 4.0, 4.1 4.2 around, around, around 4.3 around, around 4.4, 4.5, 4.6, 4.7, around, around, around around 4.8, 4.9, around around around 5.0, 5.1, 5.2, 5.3, 5.4, around, around, around around around 5.5, 5.6, 5.7, 5.8, around, around 5.9, or some Dor 6.0.Claim 57: the isolated Nucleic Acid according to claim 56, where the heavy chain is encoded by a Nucleic Acid comprising a Nucleotide sequence of at least 90% identical to the Nucleotide sequence of SEQ ID described in SEQ ID no. 3, no. 4, SEQ ID no. 5, SEQ ID SEQ ID no. 6, no. 7, SEQ ID No. 8, or SEQ ID no. 9.Claim 61: the expression vector according to claim 60, where the isolated Nucleic Acid encoding light chain of Antibody. Claim: 67 recombinant host Cell according to claim 66, where the host Cell secreted an Antibody that binds t
