[Problem] To provide an anti human Tie2 antibody which prevents or treats diabetic macular edema diabetic retinopathy or critical limb ischaemia by binding to human Tie2 and activating human Tie2. [Solution] The inventors of the present invention studied anti human Tie2 antibodies and have provided an anti human Tie2 antibody including four heavy chain variable regions and four light chain variable regions. The heavy chain variable regions comprise an amino acid sequence from amino acid no. 1 to 122 of SEQ ID NO:2 and the light chain variable regions comprise an amino acid sequence from amino acid no. 1 to 113 of SEQ ID NO:4. One of the heavy chain variable regions and one of the light chain variable regions constitute one antigen binding site and the antibody includes four antigen binding sites.
