The invention relates to the therapeutic or non-therapeutic use of tyrothricin for the treatment and/or prophylaxis of body odour in humans, preferably by local (topical) surface application and/or preferably by application to wound-free skin and/or mucosa. A therapeutic, preferably pharmaceutical, or non-therapeutic, preferably cosmetic, composition is described for the treatment and/or prophylaxis of body odour in humans, the composition containing tyrothricin and a keratolytic. A kit, containing tyrothricin and a keratolytic, and a footwear article, which contains tyrothricin, are also described.