What is described is the therapeutic or nontherapeutic use of tyrothricin for treatment and/or prophylaxis of human body odor, preferably by local (topical), superficial application and/or preferably by application to the wound-free skin and/or mucosa. Further described is a therapeutic, preferably pharmaceutical, or nontherapeutic, preferably cosmetic, composition, comprising tyrothricin and a keratolytic, for treatment and/or prophylaxis of human body odor. Likewise described are a kit comprising tyrothricin and a keratolytic, and a footwear article comprising tyrothricin.