Jan G. J. VAN DE WINKEL,Marcus Antonius VAN DIJK,Edward HALK,Arnout F. GERRITSEN,Jørgen PETERSEN,Ole BAADSGAARD
申请号：
US14055222
公开号：
US20140141006A1
申请日:
2013.10.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
