Jan G. J. van de Winkel;Marcus Antonius van Dijk;Arnout F. Gerritsen;Ole Baadsgaard;Edward Halk;Jorgen Petersen
发明人:
Jan G. J. van de Winkel,Marcus Antonius van Dijk,Edward Halk,Arnout F. Gerritsen,Jorgen Petersen,Ole Baadsgaard
申请号：
US12464057
公开号：
US08586041B2
申请日:
2009.05.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
