VAN DE WINKEL, JAN, G., J.,VAN DIJK, MARCUS, ANTONIUS,SCHUURMAN, JANINE,GERRITSEN, ARNOUT, F.,BAADSGAARD, OLE
申请号：
HK04109618.9
公开号：
HK1066828B
申请日:
2004.12.06
申请国别(地区):
HK
年份:
2012
代理人:
摘要：
Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
