PAUL PARREN,HAICHUN HUANG,JAN G. J. VAN DE WINKEL,JESSICA@WOODMILL COTTAGE TEELING,SIGRID RUULS,MARTIN GLENNIE,JORGEN PETERSEN,OLE D. M. SC. BAADSGAARD
申请号：
PT03809145
公开号：
PT1558648E
申请日:
2003.10.17
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
