Jessica Teeling,Sigrid Ruuls,Martin Glennie,Jan G.J. van de Winkel,Paul Parren,Jørgen Petersen,Ole Baadsgaard,Haichun Huang
申请号：
US16689361
公开号：
US20200317799A1
申请日:
2019.11.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
