ANHYDROUS POLYMORPHS OF ((2R,3S,4R,5R)-5-(6-(CYCLOPENTYLAMINO)-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL) METHYL NITRATE AND PROCESSES OF PREPARATION THEREOF

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专利权人:

INOTEK PHARMACEUTICALS CORPORATION;이노텍 파마슈티컬스 코포레이션

发明人:

MCVICAR WILLIAM K.,맥비커 윌리암 케이

申请号：

KR1020147021261

公开号：

KR1020140128974A

申请日:

2013.01.25

申请国别(地区):

KR

年份:

2014

代理人:

摘要：

The present invention provides a novel anhydrous polymorph form of [(2R,3S,4R,5R) -5-(6-(cyc]opentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)]methyl nitrate (Compound A). The present invention also provides processes for preparation of the anhydrous polymorphic form of compound A, compositions containing the polymorph form, and use of the polymorph form for the preparation of ophthalmic compositions.본 발명은 ((2R,3S,4R,5R)-5-(6-(시클로펜틸아미노)-9H-퓨린-9-일)-3,4-디히드록시테트라히드로푸란-2-일) 메틸 니트레이트(화합물 A)의 신규한 무수 다형체 형태들을 제공한다. 본 발명은 또한 화합물 A의 무수 다형체 형태들의 제조 방법들을 제공한다.

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