Provided is a pharmaceutical composition comprising: a) a prostaglandin compound (b) a sugar alcohol (c) a polyol and (d) a pharmaceutically acceptable carrier. The composition of the present invention can be stored stably even in a polyethylene container. In addition, the composition of the present invention can be stored stably for a long term even if it comprises only a small amount of a preserving agent.本發明係提供一種醫藥組成物,其包含:a)前列腺素化合物;(b)糖醇;(c)多元醇;及(d)醫藥上可接受之載劑。本發明之組成物即使於聚乙烯容器中仍可安定存放。此外,即使本發明之組成物僅包含少量防腐劑,其仍可長期安定存放。