Pharmaceutical compositions for reducing frequency of urination are disclosed. The pharmaceutical compositions comprise one or more prostaglandin pathway inhibitors and a pharmaceutically acceptable carrier. Also disclosed are methods of making and using the pharmaceutical compositions.本發明揭示用於降低排尿頻率之醫藥組成物。該醫藥組成物係包含一或多種前列腺素路徑(prostaglandin pathway)抑制劑及醫藥上可接受之載劑。本發明亦揭示製造或使用該醫藥組成物的方法。