A double-emulsion core-shell nano structure and preparation methods thereof is provided. The double-emulsion core-shell nano structure is a structure of an oil shell enclosing a water core. The double-emulsion core-shell nano structure can be prepared by simply mixing and stirring to emulsify an aqueous solution of a water soluble polymer and an organic solution of hydrophobic paramagnetic nanoparticles.本發明提供一種雙乳化核殼奈米結構及其製備方法。雙乳化核殼奈米結構係由油相殼包覆水相核而成。可藉由使用單一混合攪拌步驟來乳化水溶性高分子之水溶液與疏水性順磁奈米粒子之有機溶液,而可製得雙乳化核殼奈米結構。100...雙乳化核殼奈米結構110...油相殼115...水溶性高分子120...疏水性順磁奈米粒子125...水相核