The invention provides a method for guiding the acquisition of ultrasound data. The method begins by obtaining ultrasound data from a plurality of data acquisition planes and performing spatial registration of the data acquisition planes. A number of vessels are then identified in each data acquisition plane. A location of a vessel bifurcation is then identified based on the spatial registration of the data acquisition planes and the number of vessels in each data acquisition plane. A guidance instruction is generated based on the location of the vessel bifurcation, wherein the guidance instruction is adapted to indicate a location to obtain further ultrasound data.