PROBLEM TO BE SOLVED: To provide a patch for external use capable of stably maintaining high medicine releasability and percutaneous absorption by a simple means without changing physical properties of medicine itself.SOLUTION: In the patch for external use containing an acidic medicine in an adhesive base, precipitation of medicine crystal is largely improved, and high releasability and percutaneous absorption are maintained by addition of an extremely small amount of a monovalent and/or divalent metal hydroxide.COPYRIGHT: (C)2011,JPO&INPIT【課題】製剤自体の物性を変化させることなく、かつ簡単な手段で、薬物の高い放出性及び経皮吸収性を安定的に維持することが可能な外用貼付剤を提供する。【解決手段】酸性薬物を粘着基剤に含有させた外用貼付剤において、微量の1価及び/又は2価の金属水酸化物を配合することで薬物結晶の析出を大幅に改善できる上、高い放出性及び経皮吸収性を維持することが可能となる。【選択図】なし
