BOLLBUCK, Birgit,ROEHN, Till,MILTZ, Wofgang,MARKERT, Christian
申请号：
PE0008462016
公开号：
PE08992016A1
申请日:
2014.12.18
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
The present Invention relates to heteroaryl butanoic acid acid Derivatives of formula (i), wherein R1 is Oh or NH2 and is o, s or CH2 x1, X2, X3 and X4 are n or X1, X2, X3 and X4 are selected from N, NH, among others, provided that the least two X1, X2, X3 and X4 are n or NH R2 is alkyl of C1 - C6, among others. You.Preferred compounds are: acid (R) - 3-amino-4 - (5 - (4 - (benzo [d thiazole - 2 - iloxi) phenyl) - 2H tetrazole - 2 - il) butanoic acid acid (R) - 3-amino-4 - (5 - (4 - ((IL - 2 - 5 - cloropiridin) Oxy) phenyl) - 2H tetrazole - 2 - il) butanoic acid, among others. It also relates to a Pharmaceutical composition containing same.These compounds are inhibitors of Leukotriene A4 hydrolase (LTA4H), being useful in the treatment of inflammatory disorders such as arthritis, allergies, among othersLa presente invencion se refiere a derivados de acido heteroaril butanoico de formula (I), en donde R1 es OH o NH2 Y es O, S o CH2 X1, X2, X3 y X4 son N o X1, X2, X3 y X4 se seleccionan de N, NH, entre otros, siempre que al menos dos de X1, X2, X3 o X4 sean N o NH R2 es alquilo C1-C6, entre otros. Son compuestos preferidos: acido (R)-3-amino-4-(5-(4-(benzo[dtiazol-2-iloxi)fenil)-2H-tetrazol-2-il)butanoico acido (R)-3-amino-4-(5-(4-((5-cloropiridin-2-il)oxi)fenil)-2H-tetrazol-2-il)butanoico entre otros. Tambien se refiere a una composicion farmaceutica que lo comprende. Dichos compuestos son inhibidores de leucotrieno A4 hidrolasa (LTA4H), siendo utiles en el tratamiento de trastornos de la inflamacion como artritis, alergias, entre otros
