process of preparing a beta-nucleoside compound and compound

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专利权人:

PHARMAESSENTIA CORPORATION

发明人:

CHI-YUAN CHU

申请号：

BRPI0817364

公开号：

BRPI0817364A2

申请日:

2008.11.06

申请国别(地区):

BR

年份:

2019

代理人:

摘要：

This invention relates to a process of stereoselectively synthesizing a &bgr；-nucleoside compound of formula (I): wherein R1, R2, and B are as defined in the specification； each of R3 and R4, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetrahydrofuran compound of formula (II): wherein R1, R2, and L are as defined in the specification, with a nucleobase derivative； and each of R3 and R4, independently, is H or fluoro.

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