STEREOSELECTIVE SYNTHESIS OF BETA-NUCLEOSIDES

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专利权人:

发明人:

申请号：

EP12163289.7

公开号：

EP2508528A1

申请日:

2012.04.05

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

A process of stereoselectively synthesizing β-nucleoside of formula (I), e.g., 2-deoxy-2,2-difluorocytidine, is described. The process includes reacting a tetrahydrofuran compound of the following formula:in which wherein R1, R2, R3, R4, and L as defined in the specification, with a nucleobase derivative in the presence of an oxidizing agent.

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