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СПОСОБ ТЕРАПИИ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ
专利权人:
СЕНТРО ДЕ ИНХЕНЬЕРИЯ ХЕНЕТИКА И БИОТЕКНОЛОХИЯ (CU)
发明人:
ГЕРРА ВАЛЬЕСПИ Марибель (CU),ФЕРНАНДЕС МАССО Хулио Рауль (CU),МУСАКЧИО ЛАСА Алексис (CU),ХИЛ ВАЛЬДЕС Хеованис (CU),РЕЙЕС АКОСТА Освальдо (CU),ОЛИВА АРГЕЛЬЕС Брисайда Майлин (CU)
申请号:
RU2012157289/10
公开号:
RU2012157289A
申请日:
2011.05.31
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method for treatment of cancer, which is characterized by an increase in the nuclear localization of the protein in the cell COMMD1 malignant tumor, which causes a decrease in or blocking proliferation of said kletki.2. The method of claim 1, wherein the cell is a malignant tumor is contacted with an agent which increases the protein COMMD1 nuclear localization in a cell malignant tumor, or a composition containing the agent which enhances protein COMMD1 nuclear localization in a cell malignant tumor, which is introduced subektu.3. A method according to claim 2, wherein the agent which enhances protein COMMD1 nuclear localization in cells of malignant tumors, the peptide comprises the amino acid sequence identified as SEQ ID №3.4. A method according to claim 3, characterized in that the inhibition of tumor development associated with inflammation and metastazami.5. A method according to claim 4, wherein the tumor associated with inflammation and metastasis located in the colon, rectum, esophagus, lungs, prostate, breast, pancreas or pecheni.6. A method according to claim 2, wherein the agent which enhances protein COMMD1 nuclear localization in a cell malignant tumor, comprising an expression vector for mammal which comprises a DNA sequence of a cell that encodes COMMD1 protein comprising a nuclear localization sequence (NLS) .7. Use of an agent that increases the protein nuclear localization COMMD1, in the manufacture of a medicament for the treatment of malignant opuholi.8. Use according to claim 7, wherein the agent which enhances protein nuclear localization COMMD1, is a protein syn1. Способ терапии злокачественной опухоли, который характеризуется увеличением ядерной локализации белка COMMD1 в клетке злокачественной опухоли, которое вызывает снижение или блокирование пролиферации указанной клетки.2. Способ по п.1, где клетка злокачественной опухоли контактирует со средством, которое увеличивает ядерную локализацию белка COMMD1 в клетке злокачественной опухо
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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