1-(5-BROMO-2-HYDROXY-4-METHOXYPHENYL)ETHANONE AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME WITH ANTI-INFLAMMATORY EFFECT BY A MECHANISM WHICH BLOCKS MAPK PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF NF-KAPPAB
PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
发明人:
KIM, SE KWON,김세권,S.W.A. HIMAYA,에스.더블유.에이. 히마야,RYU, BO MI,류보미,ZHONG JI QIAN,중-지 첸
申请号：
KR1020110101345
公开号：
KR1020130037029A
申请日:
2011.10.05
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A 1-(5-bromo-2-hydroxy-4-methoxyphenyl)ethanone compound with anti-inflammatory effect and a pharmaceutical composition containing the same are provided to prevent or treat inflammation-mediated neurodegenerative diseases.CONSTITUTION: A 1-(5-bromo-2-hydroxy-4-methoxyphenyl)ethanone compound has inflammatory effect and is denoted by chemical formula 1. The compound blocks NF-kappaB and MAPK signaling pathway. The compound prevents or treats Alzheimers disease, Parkinsons disease, myasthenia gravis, multiple sclerosis, Huntingtons chorea, or progressive muscle dystrophy. The compound is derived from Paeonia suffruticosa ANER or hippocampus. A pharmaceutical composition for anti-inflammation contains the compound.COPYRIGHT KIPO 2013본 발명은 항염증 효과를 갖는 1-(5-브로모-2-하이드록시-4-메톡시페닐)에타논 화합물 및 이를 함유하는 약학 조성물에 관한 것으로, MAPK 분자의 인산화 및 NF-κB의 핵 전좌를 차단하는 메카니즘에 의해 항염증 효과 및 염증-매개된 신경퇴행성 질환의 예방 또는 치료 효과를 가지며, 특히 SE1 화합물의 분자 크기가 작기 때문에 혈액-뇌 장벽을 쉽게 통과할 수 있어 알츠하이머와 같은 뇌 손상 질환을 예방 또는 치료할 수 있는 현저히 우수한 효과를 갖는다.
