COMPOUND BINDING TO PPARG BUT NOT ACTING AS PROMOTER AND PHARMACEUTICAL COMPOSITION FOR TREATING PPARG-RELATED DISEASES CONTAINING SAME AS ACTIVE INGREDIENT
LEE, In Hee,CHAE, Hee Il,KIM, Se hoan,MOON, Soon Young,HA, Tae Young,CHOI, Hyo sun,KIM, Young Seok,KIM, Chun hwa,RHEE, Jae Keol
申请号:
EP15764627
公开号:
EP3121167A4
申请日:
2015.02.27
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention relates to a compound inhibiting CDK5-mediated PPARG phosphorylation and a pharmaceutical composition for treating PPARG-related diseases containing the same as an active ingredient. A compound represented by formula 1 or an optical isomer thereof according to the present invention binds to PPARG at a high affinity level, but does not act as an agonist, thereby inducing no gene transcription blocks CDK5, which is a cause of PPARG phosphorylation, thereby causing no side effects of existing anti-diabetics can be formulated into drugs due to improved pharmacological properties thereof and can be favorably used as a pharmaceutical composition for treating PPARG-related diseases due to an excellent treatment effect on PPARG-related diseases.