Crystalline form I of tyrosine kinase inhibitor dimaleate and preparation methods thereof

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专利权人:

Jiangsu Hengrui Medicine Co.; Ltd.

发明人:

Sun, Piaoyang,Wu, Guaili,Yuan, Bo,Chen, Yongjiang

申请号：

AU2013289789

公开号：

AU2013289789B2

申请日:

2013.06.04

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7- ethoxy-quinolin-6-yl)-3-(1-methyl pyrrolidin-2-yl)propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof and pharmaceutical compositions containing the same. Said crystalline Form I of SHR1258 dimaleate has good crystal stability and chemical stability, and can be used in preparation of medicaments for treating diseases relevant to EGFR receptor tyrosine kinase or HER-2 receptor tyrosine kinase.

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