Compound binding to PPARG but not acting as promoter and pharmaceutical composition for treating PPARG-related diseases containing same as active ingredient
Lee, In Hee,Chae, Hee Il,Kim, Se hoan,Moon, Soon Young,Ha, Tae Young,Choi, Hyo sun,Kim, Young Seok,Kim, Chun hwa,Rhee, Jae Keol
申请号：
AU2015232269
公开号：
AU2015232269A1
申请日:
2015.02.27
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention relates to a compound inhibiting CDK5-mediated PPARG phosphorylation and a pharmaceutical composition for treating PPARG-related diseases containing the same as an active ingredient. A compound represented by chemical formula 1 or an optical isomer thereof according to the present invention binds to PPARG at a high affinity, but does not act as an agonist, thereby inducing no gene transcription； blocks CDK5, which is a cause of PPARG phosphorylation, thereby causing no side effects of existing anti-diabetics； can be formulated into drugs due to improved pharmacological properties thereof； and can be favorably used as a pharmaceutical composition for treating PPARG-related diseases due to an excellent treatment effect on PPARG-related diseases.
