Treatment using Bruton's tyrosine kinase inhibitors and immunotherapy

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专利权人:

Pharmacyclics LLC;The Board of Trustees of the Leland Stanford Junior University

发明人:

Levy, Ronald,Chang, Betty,Ng, Patrick,Sagiv-Barfi, Idit

申请号：

AU2020223721

公开号：

AU2020223721A1

申请日:

2020.08.27

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

#$%^&*AU2020223721A120200910.pdf#####TREATMENT USING BRUTON'S TYROSINE KINASE INHIBITORS AND IMMUNOTHERAPY ABSTRACT Combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, with immunotherapy are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2en-I-one, and an immune checkpoint inhibitor.

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