Treatment using Bruton's tyrosine kinase inhibitors and immunotherapy

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专利权人:

The Board of Trustees of the Leland Stanford Junior University;Pharmacyclics LLC

发明人:

Levy, Ronald,Chang, Betty,Ng, Patrick,Sagiv-Barfi, Idit

申请号：

AU2014339816

公开号：

AU2014339816A1

申请日:

2014.10.24

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

Combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., l-((R)-3-(4-amino-3-(4- phenoxyphenyl)- 1 H-pyrazolo [3,4-d]pyrimidin- 1 -yl)piperidin- 1 -yl)prop-2-en- 1 -one, with immunotherapy are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1- ((R)-3-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)prop-2- en-l-one, and an immune checkpoint inhibitor.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/