Jianyang Zhao;Shaoxiong Wang;Jun Lin;Joe Zhou;Xinxing Ma;Jun Wang;Jiuru Sun
发明人:
Joe Zhou,Jianyang Zhao,Jiuru Sun,Jun Wang,Shaoxiong Wang,Xinxing Ma,Jun Lin
申请号：
US12727188
公开号：
US08926972B2
申请日:
2010.03.18
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The disclosure provides a novel anti-angiogenesis fusion protein. The present invention combines a chimeric vascular endothelial cell growth factor (VEGF) receptor or a fragment thereof with a multimerizing component, which have a superior binding capacity with human VEGF and placental growth factor (PIGF). The fusion protein has improved stability, prolonged half-life and the ability to form multivalent interactions with VEGF, and can be used for anti-angiogenesis, treating VEGF related diseases and inhibiting tumor growth.
