ZHOU JOE,SUN JIURU,ZHAO JIANYANG,WANG JUN,WANG SHAOXIONG,MA XINXING,LIN JUN
申请号：
ZA201106638
公开号：
ZA201106638B
申请日:
2011.09.09
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
The disclosure provides a novel anti-angiogenesis fusion protein. The present invention combines a chimeric vascular endothelial cell growth factor (VEGF) receptor or a fragment thereof with a multimerizing component, which have a superior binding capacity with human VEGF and placental growth factor (PIGF). The fusion protein has improved stability, prolonged half-life and the ability to form multivalent interactions with VEGF, and can be used for anti-angiogenesis, treating VEGF related diseases and inhibiting tumor growth.
