There have been demands for a therapeutic method that increases the medicinal effects of taxane-based antitumor agents on various tumors. As a result of researches for a method for enhancing the antitumor effects of taxane-based antitumor agents, the inventors have achieved the present invention by confirming that a composition for the treatment of cancer, said composition containing N2-[(2E)-3-(4-chlorophenyl)-2-propenoyl]-N-[2- oxo-2-(4-{[6-(trifluoromethyl)pyrimidin-4-yl]oxy}pyperidin- 1-yl)ethyl]-3-pyridin-2-yl-L-alaninamide (FK330) or a salt thereof as an active ingredient, enhances the antitumor effects of taxane-based antitumor agents. Namely, the present invention relates to a composition for the treatment of cancer, which contains FK330 or a salt thereof as an active ingredient, and which is for administration in combination with one or more antitumor agents that are selected from among taxane-based antitumor agents.增大紫杉烷系抗腫瘤劑之對各種腫瘤的藥效之治療方法係被要求著。本發明者對紫杉烷系抗腫瘤劑之抗腫瘤作用增強方法進行探討之結果,確認含有N2-[(2E)-3-(4-氯苯基)-2-丙烯醯基]-N-[2-側氧基-2-(4-{[6-(三氟甲基)嘧啶-4-基]氧基}哌啶-1-基)乙基]-3-吡啶-2-基-L-丙胺酸醯胺(FK330)或其鹽作為有效成分之癌治療用組成物,會增強紫杉烷系抗腫瘤劑之抗腫瘤作用,而完成了本發明。亦即,本案係關於含有FK330或其鹽作為有效成分之癌治療用組成物,其係與由紫杉烷系抗腫瘤劑中選擇之1者以上的抗腫瘤劑併用投與用。
