UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION;PROTHENA THERAPEUTICS LIMITED
发明人:
DALE B. SCHENK,PETER A. SEUBERT,JONATHAN WALL,JOSÉ SALDANHA
申请号:
US15991525
公开号:
US20180360934A1
申请日:
2018.05.29
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.