Jonathan Wall;José W. Saldanha;Peter A. Seubert;Dale B. Schenk
发明人:
Dale B. Schenk,Peter A. Seubert,Jonathan Wall,José W. Saldanha
申请号:
US13187093
公开号:
US20120039878A1
申请日:
2011.07.20
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.