The present invention is related to the usage of lucidone for inhibiting for anti-inflammatory molecules production, wherein comprising reducing the expression of iNOS and COX-2. The present invention also discloses the mechanism and physiology activity of lucidone for anti-inflammatory, which is useful for novel drugs.本發明關於釣樟酮(lucidone)於抑制促發炎性分子產生的用途,其中包含降低一氧化氮合成酶或第二型環氧酶的表現。本發明並揭露釣樟酮(lucidone)於發炎反應中的作用機制與生理活性,以供新藥設計。