CHARLTON, Steven,LEBLANC, Catherine,MCKEOWN, Stephen
申请号：
ES11732449
公开号：
ES2622519T3
申请日:
2011.07.14
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound represented by Formula Ia ** Formula ** or a pharmaceutically acceptable salt thereof, wherein A is N or CR '； R 'is H, C1-C8 alkyl optionally substituted with one or more halogen atoms； R1 is H, C1-C8 alkyl optionally substituted with one or more halogen atoms, C1-C4 alkyl, OH, OR ', - NR19R21, CN or C3-C7 cycloalkyl； or R1 is -X-Y； or R1 is -W-R7-X-Y； or R1 is -S (O) 2-W-X-Y； or R1 is -S (O) 2-W-R7-X-Y； R2 is H, C1-C8 alkyl optionally substituted with one or more halogen atoms, C1-C4 alkyl, OH, OR ', -NR19R 21, CN or C3-C7 cycloalkyl； or R2 is -X-Y； or R2 is -W-R7-X-Y； or R2 is -S (O) 2-W-X-Y； R2 is -S (O) 2-W-R7-X-Y； wherein either R1 or R2 is -X-Y, -W-R7-X-Y, -S (O) 2-W-X-Y； or -S (O) 2-W-R7-X-Y； R2a is hydrogen； or R2 and R2a considered together are oxo； R3 is H, C1-C4 alkoxy, OH, -NR19R21, CN, halogen, C3-C7 cycloalkyl or C1-C8 alkyl optionally substituted with one or more halogen atoms； R4 is H, C1-C4 alkoxy, OH, -NR19R21, CN, halogen, C3-C7 cycloalkyl or C1-C8 alkyl optionally substituted with one or more halogen atoms； R5 is C1-C8 alkyl optionally substituted with one or more halogen atoms, C1-C4 alkyl, OH, OR ', -NR19R21, CN or C3-C7 cycloalkyl； C1-C8 alkoxy optionally substituted with one or more halogen atoms； C6-C14 aryl； - (C0-C4 alkyl) -heteroaryl of 4 to 14 members or - (C0-C4 alkyl) -heterocyclyl of 3 to 14 members where the heteroaryl and heterocyclyl contain at least one heteroatom selected from N, O and S, wherein the aryl, heteroaryl and heterocyclyl group are optionally substituted with one or more Z substituents； R6 is C6-C14 aryl； - (C0-C4 alkyl) -heteroaryl of 4 to 14 members, - (C0-C4 alkyl) -heterocyclyl of 3 to 14 members wherein the heteroaryl and heterocyclyl contain at least one heteroatom selected from N, O and S, wherein the aryl, heteroaryl and heterocyclyl are each optionally substituted with one or more Z substituents； W is C1-C8 alkylene optionally substituted with hydroxyl, halogens or C1-C4 alkyl； X is C1-C8 alkylene
