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METHODS FOR PREDICTION, DETECTION AND REDUCTION OF NON-SPECIFIC INTERFERENCE OF PROTEINS IN METHODS OF ANALYSIS USING SINGLE VARIABLE DOMAINS OF IMMUNOGLOBULINS
专利权人:
ABLINKS NV
发明人:
BAUMEJSTER Yudit,BUSH Mari-Pol Lyusen Armanda,BUTTON Karlo,BEJSE Mari-Anzh,SNUK Verle,STALENS Stefani
申请号:
RU20140102007
公开号:
RU2700630(C2)
申请日:
2012.06.25
申请国别(地区):
俄罗斯
年份:
2019
代理人:
摘要:
FIELD: biotechnology.SUBSTANCE: described is a compound for use in therapy, which is a polypeptide having a half-life expressed as t1/2-beta in a human for at least 3 days. Polypeptide contains a single immunoglobulin variable domain (ISV) at its C-terminal, wherein the said ISV is either VHH optimized by the VHH sequence, humanised VHH or camellated VH or is ISV, which is based on the VH (one) domain antibody based on VH dAb™ or based on the VH microbody. ISV has a C-terminal VTVSS(X)sequence, where n = 1, 2 or 3, in which each X = Ala or Gly; or n = 1, 2 or 3, in which each X = Ala; or n = 1, 2 or 3, in which each X = Gly; or n = 2 or 3, wherein at least one X = Ala or Gly; or n = 2 or 3, wherein all except one X = Ala or Gly. Polypeptide also contains a peptide which binds serum albumin or a serum albumin binding domain.EFFECT: invention enables solving the problem of protein interference in ADA-analysis.22 cl, 9 dwg, 12 tbl, 9 ex
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