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NIR MATERIALS AND NANOMATERIALS FOR THERANOSTIC APPLICATIONS
专利权人:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION; INC.
发明人:
BROWN, SCOTT, CHANG,GROBMYER, STEPHEN, R.,SINGH, AMIT, KUMAR,MOUDGIL, BRIJ, M.,SHARMA, PARVESH
申请号:
EP11751091
公开号:
EP2552825A4
申请日:
2011.02.24
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Novel fluorescent dye comprising metal oxide nanoparticles are prepared where the nanoparticles are as small as 3 nm or up to 7000 nm in diameter and where the dye is bound within the metal oxide matrix. In some embodiments the invention, novel dyes are covalently attached to the matrix and in other embodiments of the invention a dye is coordinate or ionic bound within the metal oxide matrix. A method for preparing the novel covalently bondable modified fluorescent dyes is presented. A method to prepare silica comprising nanoparticles that are 3 to 8 nm in diameter is presented. In some embodiments, the fluorescent dye comprising metal oxide nanoparticles are further decorated with functionality for use as multimodal in vitro or in vivo imaging agents. In other embodiments of the invention, the fluorescent dye comprising metal oxide nanoparticles provide therapeutic activity and incorporated therapeutic temperature monitoring.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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