The Board of Regents of The University of Texas System;Zhou, Jia;Ding, Chunyong;Cunningham, Kathryn A.
发明人:
申请号：
EP12855886.3
公开号：
EP2809156A2
申请日:
2012.12.07
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same. Certain embodiments also include methods of identifying and methods of synthesizing the compounds. Optimization and development of allosteric 5-HT 2CR modulators that bind sites other than the primary ligand binding site generate novel, highly selective, and potent ligands of 5-HT2CR. Such molecules can be used as small molecule probes for the nervous system and as effective therapeutics for a variety of diseases.Les formes de réalisation de l'invention concernent des procédés d'identification, des procédés de synthèse et des compositions identifiées en tant que modulateurs allostériques du 5-HT2cR.
