THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM;ZHOU, JIA;DING, CHUNYONG;CUNNINGHAM, KATHRYN A.
发明人:
ZHOU, JIA,DING, CHUNYONG,CUNNINGHAM, KATHRYN, A.
申请号：
EP12855886
公开号：
EP2809156A4
申请日:
2012.12.07
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same. Certain embodiments also include methods of identifying and methods of synthesizing the compounds. Optimization and development of allosteric 5-HT 2CR modulators that bind sites other than the primary ligand binding site generate novel, highly selective, and potent ligands of 5-HT2CR. Such molecules can be used as small molecule probes for the nervous system and as effective therapeutics for a variety of diseases.
