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MODULATEURS ALLOSTERIQUES DU RECEPTEUR 5-HYDROXYTRYPTAMINE 2C (5-HT2CR) A PETITE MOLECULE FONDES SUR LA PIPERIDINE
专利权人:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
ZHOU, JIA,DING, CHUNYONG,CUNNINGHAM, KATHRYN A.
申请号:
CA2871766
公开号:
CA2871766A1
申请日:
2012.12.07
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same. Certain embodiments also include methods of identifying and methods of synthesizing the compounds. Optimization and development of allosteric 5-HT 2CR modulators that bind sites other than the primary ligand binding site generate novel, highly selective, and potent ligands of 5-HT2CR. Such molecules can be used as small molecule probes for the nervous system and as effective therapeutics for a variety of diseases.
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