Gray, Jeffrey Lyle,Clark, Cynthia Monesa,Amarasinghe, Kande K.D.,Maier, Mathew Brian,Nichols, Ryan
申请号：
ES12196174
公开号：
ES2650598T3
申请日:
2007.06.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound having the formula: ** Formula ** wherein R is a substituted or unsubstituted thiazolyl unit having the formula: ** Formula ** R4 is selected from: i) hydrogen； ii) substituted or unsubstituted linear, branched or cyclic C1-C6 alkyl； said substitutions are selected from halogen and OR11； wherein R11 is linear or branched C1-C4 alkyl； iii) phenyl, 3,4-dimethylphenyl, 10 4-tert-butylphenyl, 4-cyclopropylphenyl, 4-diethylaminophenyl, 4- (trifluoromethyl) phenyl, 4-methoxyphenyl, 4- (difluoromethoxy) phenyl, 4- (trifluoro-methoxy) phenyl, 3-chlorophenyl, 4-chlorophenyl and 3,4-dichlorophenyl； iv) thiophene-2-yl, 5-chlorothiophene-2-yl, 5-methylthiophene-2-yl, thiophene-3-yl, 5-chlorothiophene-3-yl and 5-methylthiophene-3-yl； R6 is selected from: hydrogen, methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, phenyl, 2-fluorophenyl, 2-chlorophenyl, 2-methylphenyl, 2 -methoxyphenyl, 3-fluorophenyl, 3-chlorophenyl, 3-methylphenyl, 3- methoxyphenyl, 4-fluorophenyl, 4-chlorophenyl, 4-methylphenyl, 4-methoxyphenyl, 1,2,3,4-tetrazol-1-yl, 1 , 2,3,4-tetrazol-5-yl, [1,2,3] triazol-4-yl, [1,2,3] triazol-5-yl, [1,2,4] triazol-4- yl, [1,2,4] triazol-5-yl, imidazol-2-yl, imidazol-4-yl, pyrrole-2-yl, pyrrole-3-yl, oxazol-2-yl, oxazol-4-yl , oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, [1,2,4] oxadiazol-3-yl, [1,2,4] oxadiazol-5-yl , [1,3,4] oxadiazol-2-yl, furan-2-yl, furan-3-yl, thiophene-2-yl, thiophene-3-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, [1,2,4] thiadiazol-3-yl, [1,2,4] thiadiazol-5-yl or [1,3,4] thiadiazol-2-yl； R1 is selected from: i) hydrogen； ii) linear or branched C1-C6 alkyl； or iii) benzyl； R2 is selected from: i) linear or branched C1-C6 alkyl； or ii) linear or branched C1-C6 alkoxy； or a pharmaceutically acceptable salt thereof.Un compuesto que tiene la fórmula:**Fórmula** en donde R es una unidad de tiazolilo sustituida o sin sustituir que tiene la fórmula:**F
