SUBSTITUTED AZOL DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THESE DERIVATIVES, AND METHODS OF TREATING PARKINSON'S DISEASE WITH USING THESE DERIVATIVES

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专利权人:

LTD.;SK BAJOFARMASJUTIKALZ KO.

发明人:

PARK CHeol-KHong (KR),ПАРК Чеол-Хьонг (KR),MIN KHe-Kjung (KR),МИН Хье-Кьюнг (KR),LIM Mi-Dzhung (KR),ЛИМ Ми-Джунг (KR),LI Dzhi-Von (KR),ЛИ Джи-Вон (KR),CHUNG Dzhin-Jon (KR),ЧУНГ Джин-Йон (KR),RJU CHun-,PARK CHEOL-KHONG,ПАРК Чеол-Хьонг,MIN KHE-KJUNG,МИН Хье-Кьюнг,LIM MI-DZHUNG,ЛИМ Ми-Джунг,LI DZHI-VON,ЛИ Джи-Вон,CHUNG DZHIN-JON,ЧУНГ Джин-Йон,RJU CHUN-KHO,РЮ Чун-Хо,JUN JEO-DZHIN,ЮН Йео-Джин,DZHI MI-KJ

申请号：

RU2011134423/04

公开号：

RU0002578596C2

申请日:

2010.02.25

申请国别(地区):

RU

年份:

2016

代理人:

摘要：

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a substituted azol derivative presented by the following formula (I)3-(4-benzyloxy-3,5-dimethyl-phenyl)-isoxazol-5-ylmethyl ester of carbamic acid, 3-(4-prop-2-inyl-oxyphenyl)-isoxazol-5-ylmethyl ester of carbamic acid or 2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-ylmethyl]-amino}-propionamide or its pharmaceutically acceptable salt, wherein R is specified in a group consisting of C4-C15 arylalkyl unsubstituted or substituted by at least one substitute specified in a group consisting of halogen, trifluoromethyl, trifluoralkoxy, -NO2, C(=O)OCH3, linear or branched C1-C6 alkyl, C1-C6 alkoxy, phenyl, phenyloxy, benzyloxy, -C(=O)H, -OH and -C=N-OH； C4-C15 heteroarylalkyl unsubstituted or substituted by at least one substitute specified in a group consisting of halogen, C(=O)OCH3, linear or branched C1-C6 alkyl, C1-C6 alkoxy, phenyl, phenyloxy, benzyloxy； linear, branched or cyclic C1-C10 alkyl substituted by at least one substitute specified in a group consisting of C1-C3-alkyloxy, C1-C3 alkylthio, carbamate, tert-butyl-OC(=O)NH-, -NH3 +, -NH2, -OH, -C(=O)OCH2CH3, -NHC(=O)NH2, trifluoromethylsulphanyl, trifluoromethyl and -CN； wherein when R represents C4-C15-heteroarylalkyl, a heteroaryl group is specified in a group consisting of imidazol, chlorthiophen, benzothiazol, pyridine, quinoline, benzotriazol, isoxazol, furan, N-oxopyridine, N-methylpyridine and benzo[1,3]dioxol, and when R means C4-C15 arylalkyl, wherein aryl is specified in a group consisting of phenyl, phenyloxy, benzyloxy and naphthalinyl, Y is specified in a group consisting of O and N - R1, R1 means a substitute specified in a group consisting of H and linear or branched C1-C3 alkyl； R2 is specified in a group consisting of H and halogen； A is specified in a group consisting of O and S； B represents C； Z is specified in a group consisting of imidazol, pyrrolidine and tetrazol unsubstituted or substituted by at least one substitute specified in a g

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